Treatment GuideJuly 12, 2026

Rejuran and Skin Boosters: Understanding the Principles and Types of Salmon Injections

By K-DermZip Editorial Team·Based on HIRA public data·Editorial policy
Rejuran and Skin Boosters: Understanding the Principles and Types of Salmon Injections

Rejuran, Skin Boosters, and Salmon Injections: What Are They?

Rejuran is one of the representative skin boosters, primarily composed of polynucleotide (PN) extracted from salmon DNA. It is often referred to as 'salmon injection' and can help improve the internal skin environment, activate self-regenerative capacity, and promote overall skin health. Skin booster is a general term for procedures that inject active ingredients directly into the skin to achieve various effects such as skin regeneration, moisturizing, and elasticity improvement.

Rejuran, Salmon Injection's Key Ingredient: Polynucleotide (PN)

The main ingredient of Rejuran, polynucleotide (PN), is a biocompatible material made by purifying DNA fragments extracted from salmon testes. This PN has a structure similar to human DNA, and thus is known to have low rejection rates and be safe when injected into the skin. PN can contribute to skin improvement in the following ways:

  • Promote Skin Regeneration: It can help regenerate damaged skin cells, promote collagen and elastin production, and strengthen skin structure.
  • Strengthen Skin Barrier: It can restore the skin's natural protective function, protect the skin from external stimuli, and help reduce moisture loss.
  • Anti-inflammatory and Wound Healing: It can alleviate inflammatory responses and contribute to promoting wound healing processes.
  • Regulate Oil-Water Balance: It can balance the skin's oil and moisture, suppress excessive sebum secretion, and improve dryness.

Various Types and Characteristics of Rejuran

Rejuran is divided into various types depending on skin concerns and treatment areas. The main Rejuran products are as follows:

  • Rejuran Healer: As the most basic Rejuran product, it aims for overall skin health improvement, including facial skin regeneration, elasticity improvement, fine wrinkle reduction, and oil-water balance regulation.
  • Rejuran I: The skin around the eyes is thinner and more sensitive than other areas, requiring specialized care. Rejuran I was developed to help improve concerns around the eyes such as fine wrinkles, dark circles, and loss of elasticity.
  • Rejuran HB: This product combines Rejuran Healer with hyaluronic acid and lidocaine (a local anesthetic). The addition of hyaluronic acid enhances moisturizing effects, and the inclusion of lidocaine can help reduce pain during the procedure.
  • Rejuran S: As a product specialized for scar improvement, it has higher viscosity than regular Rejuran Healer and can be used to fill in depressed scar areas with volume and induce skin regeneration.

In addition to these, Rejuran has been developed in various forms, providing customized solutions for specific skin concerns. It is important to determine which Rejuran product is suitable for you through consultation with a medical professional.

Types and Effects of Skin Boosters Other Than Rejuran

In addition to Rejuran, there are skin boosters with various ingredients and purposes. Representative skin boosters are as follows:

  • Hyaluronic Acid Skin Booster: By injecting highly concentrated hyaluronic acid, it provides deep hydration within the skin and helps strengthen the skin barrier function. It can be effective for dry and dull skin, and for improving fine wrinkles.
  • Exosome Skin Booster: By utilizing exosomes extracted from stem cell culture medium, it can promote signal transmission between skin cells and contribute to enhancing regenerative capacity. It can help with anti-inflammation, skin barrier strengthening, and elasticity improvement.
  • Amino Acid/Vitamin Complex Skin Booster: By injecting a complex of essential amino acids, vitamins, and minerals for skin composition, it is used to boost skin vitality and improve overall skin condition. Skin tone improvement, antioxidant effects, etc. can be expected.
  • Collagen Booster: By injecting ingredients that promote collagen production (e.g., PCL, PLLA), it can help improve skin elasticity and add volume. It may primarily be considered for concerns such as skin sagging or loss of elasticity.

Since each skin booster has different main ingredients and mechanisms of action, it is essential to consult with a dermatologist to choose the most suitable procedure for your skin type and concerns.

Rejuran and Skin Booster Procedure Process and Precautions

Skin booster procedures, including Rejuran, generally follow the process below:

  1. Consultation and Diagnosis: Through consultation with a medical professional, the skin condition is accurately diagnosed, and the appropriate skin booster type and treatment plan are established.
  2. Anesthesia: Anesthetic cream is applied to the treatment area to reduce pain. Products containing lidocaine, such as Rejuran HB, may result in less pain.
  3. Injection Procedure: Using a fine needle, the skin booster is directly injected into the dermal layer of the skin. Depending on the treatment method, manual injection or an injector device may be used.
  4. Post-procedure Care: Redness, swelling, and a bumpy appearance may occur after the procedure, which usually disappear naturally within a few days. According to the medical staff's instructions, appropriate post-procedure care such as cold compresses and application of regenerative cream is necessary.

Precautions:

  • It is advisable to avoid alcohol consumption, smoking, and strenuous exercise for a certain period after the procedure.
  • Exposure to high-temperature environments such as saunas and jjimjilbangs should be avoided.
  • Be careful not to rub or irritate the treated area excessively.
  • The effects and duration may vary depending on individual skin conditions, and side effects may occur.

This article provides general medical information and does not replace individual diagnosis, treatment, or prescription. If you are considering a skin procedure, it is important to consult thoroughly with a dermatologist to establish a treatment plan suitable for you.

Clinics with Registered Related Procedure Information

This is an alphabetical guide and not a ranking or medical recommendation. Procedure information is based on content registered by each clinic. (Source: Keudeomjip)

K-DermZip is a specialized Korean dermatology platform based on HIRA public data. This content is informational and complies with Korean medical advertising regulations.