NCTF, PDRN, and Salmon Injections: What Sets Skin Boosters Apart?
What people commonly call a 'water glow injection' or 'skin booster' at a dermatology clinic actually covers several distinct ingredients. The most frequently compared options are NCTF (Filorga), PDRN-based salmon injections, and Rejuran. Although the names sound similar, their core ingredients and mechanisms differ meaningfully, so it helps to understand each before deciding on an approach.
What is NCTF made of?
NCTF is a hyaluronic-acid-based formula that combines vitamins, minerals, amino acids, and antioxidant compounds into a single mixture. It is thought to work by delivering hydration and nutrients to the epidermis and dermis, and is commonly used to improve skin texture or dullness. That said, this is closer to a nourishing, hydrating treatment, and it would be inaccurate to claim immediate or permanent improvement in wrinkles or elasticity.
How does PDRN (salmon injection) differ from NCTF?
PDRN (polydeoxyribonucleotide) is a purified DNA fragment extracted from salmon or trout reproductive cells, commonly marketed as a 'salmon injection.' Research has explored how PDRN stimulates adenosine A2A receptors involved in cell regeneration and tissue repair, promoting the release of growth factors. Because of this, it is often used for wound healing, post-acne scar recovery, and strengthening the skin barrier. While NCTF leans toward nutrient-based hydration, PDRN focuses more on signaling tissue regeneration — a fundamentally different approach.
How is Rejuran different?
Rejuran is also PDRN-based, but products vary by concentration, purification method, and viscosity. Rejuran is generally introduced as containing a relatively higher PDRN concentration, positioned toward skin regeneration and elasticity improvement. However, it is difficult to declare one product superior to another, since the right choice depends on individual skin condition and treatment goals.
What happens if swelling or bruising occurs after treatment?
Skin booster treatments typically involve injecting the substance into the dermis using fine needles or a cannula, so temporary swelling, redness, or bruising at the injection site is possible. These reactions usually subside naturally within a few days, though individual recovery times vary. If swelling or bruising persists longer than expected, or is accompanied by pain or fever, it is advisable to contact the clinic where the procedure was performed.
Which ingredient should you choose?
Choosing an ingredient should not be based on trends or price alone. The appropriate ingredient and treatment interval can vary depending on skin type, current condition (dryness, reduced elasticity, scarring, etc.), and treatment goals. Those who are pregnant, breastfeeding, or have certain autoimmune conditions or allergy histories should confirm eligibility beforehand. It is important to understand the differences between ingredients and consult a specialist to find what suits your skin.
This information is provided for general reference only. Please consult a board-certified dermatologist for accurate diagnosis and treatment.
Find more information on our skin health blog.